Kardioprotekcja – analiza publikacji dotyczących protekcji mięśnia sercowego

Bartosz Andrzej Kuźlik; Małgorzata Gawlak; Marta Mazur; Katarzyna Ciesielska; Piotr Buszman; Krzysztof Sanetra

doi:10.48269/2451-0858-pis-2024-2-010

Published: 2024-12-18

Vol. 24 No. 2 (2024)

Cardioprotection: an analysis of publications on myocardial protection

Bartosz Andrzej Kuźlik

, Małgorzata Gawlak

, Marta Mazur

, Katarzyna Ciesielska

, Piotr Buszman

, Krzysztof Sanetra

Section: Health Sciences

https://doi.org/10.48269/2451-0858-pis-2024-2-010

Abstract

The pathophysiology of a reperfusion injury, which poses a challenge after a cardiac ischemic episode, is not fully understood. Several molecular processes show possible ways to counteract this phenomenon. One is to prepare the heart for the onset of an ischemic episode, which can be achieved by physical training of the patient or pharmacotherapy. Another approach is to act pharmacologically on the miRNA or NRF2 family of transcription factors.
Crucial for cardiac surgery is the use of an appropriate cardioplegin solution and to administer it correctly. Recent studies have focused particularly on the use of del Nido cardioplegin, which, when administered, allows for the extension of safe myocardial ischemia for up to 120 minutes in higher-risk patients. The use of trimetazidine makes it possible to reduce cardiovascular risk in older patients after surgery, and the administration of Alfacalcidol before valve surgery reduces the risk of perioperative complications.
By inducing pathological conditions in animals, it is possible to test compounds that can counteract these phenomena or reduce their severity. Compounds such as disulfiram, crocin, stachytin, gosypine, or metformin in combination with hydrogen can reduce the risk of cardiovascular complications and cardiac remodelling.
Cardioprotection is important in the pediatric population because of the effects of some therapies that cause iatrogenic myocardial damage. Administration of dexrazoxane or glutathione in combination with doxarubicin therapy can reduce myocardial damage in the pediatric population without reducing the efficacy of the chemotherapeutics. The cardioprotective effects of carvedilol, captopril, simvastatin and L-carnitine, as well as some supplements, have also been demonstrated.

Keywords:

pediatric oncology , reperfusion injury , carioprotection , cardiosurgery , vascular surgery , pediatric cardioprotection

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Kuźlik, Bartosz Andrzej, et al. “Cardioprotection: An Analysis of Publications on Myocardial Protection”. Państwo I Społeczeństwo State and Society, vol. 24, no. 2, Dec. 2024, pp. 137-51, doi:10.48269/2451-0858-pis-2024-2-010.

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